Fenbendazole is a broad-spectrum anthelmintic that has been used for decades. It is effective against many intestinal helminths in cats and is also used to treat lungworms. A female patient with advanced nonsmall cell lung cancer received information about the antitumor activity of fenbendazole on social media and then self-administered the drug orally. She developed severe liver injury. Product Description Fenbendazole (methyl N-(6-phenylsulfanyl-1H-benzimidazol-2-yl) carbamate) is a broad-spectrum benzimidazole anthelmintic that has been used for more than 50 years. It is one of three members in the benzimidazole family of drugs, which includes metronidazole and albendazole. The anthelmintic properties of fenbendazole are due to its binding to b-tubulin and disrupting microtubule assembly, which leads to detachment of parasitic worms. It is also effective against cestodes and trematodes, including Heterobilharzia americana, Neophyetus salmincola, and Platynosomum fastosum. In addition, fenbendazole has been shown to inhibit tumor growth in mouse glioma cells and to extend mean survival up to 63% in syngeneic orthotopic and xenogeneic rat glioma models. Buy fenbendazole online from desertcart, a 100% legitimate and trusted site that operates in 164 countries. Your details and transactions are protected by using latest technologies and software systems. They offer free shipping and secure checkout to all customers. Moreover, their customer support team is highly responsive and always willing to help you out in any way they can. Dosage & Administration Fenbendazole is a benzimidazole drug used as an antiparasitic against whip worm, hookworm, roundworm, and one species of tapeworm (Taenia solium). It binds to -tubulin subunits of microtubules and disrupts their polymerization. It is also an effective anthelmintic against pinworms, ascarids, and giardia. It is reported to inhibit tumor growth in both animal models and human cancer patients. It belongs to the same class of drugs as the vinca alkaloids, but has more recently been shown to have anti-oncogenic properties by targeting and destabilizing microtubules. In a murine model of allergic airway disease, fenbendazole suppressed the increase in peribronchial lymphocytes and goblet cells associated with ovalbumin exposure. It also reduced Th2-derived cytokines in blood and bronchoalveolar lavage fluid. In a small number of cases, fenbendazole has been administered as an adjunct to chemotherapy for genitourinary malignancies and appears to stall progression of the tumors in the presence of other agents. These cases have been anecdotal and do not represent official studies. Side Effects & Interactions Fenbendazole interferes with tubulin polymerization, which is necessary for the formation of microtubules (a component of the cytoskeleton). Microtubules are important for cell structures and provide stability and shape. Because of its anti-microtubulin properties, fenbendazole may have antineoplastic effects by interfering with the growth of tumor cells. It has also been shown to starve cancer cells of glucose, thus decreasing their ability to grow and reproduce. This results in regression of the tumor in laboratory settings. The long-billed vulture (Gyps indicus) is a large scavenger that relies on livestock carcasses for nutrition. However, recent research has indicated that residues of the anti-inflammatory drug diclofenac present in livestock carcasses can adversely affect Gyps vultures by disrupting intestinal cell integrity and predisposing to bacterial enteritis, ultimately leading to mortality. Warnings Fenbendazole granules should be stored in a tightly sealed container at room temperature, away from sunlight. Be sure to follow the storage recommendations provided by your veterinarian. During and after treatment, your vet may recommend fecal examinations to ensure the medication has killed parasites or that additional doses are needed. Fenbendazole belongs to a class of broad-spectrum anthelmintics called benzimidazoles (I coined this term BZ) that have been safely used as anthelmintics for nearly six decades. It is efficacious against nematodes such as Aelurostrongylus abstrusus, Baylisascaris procyonis, Crenosoma vulpis, Eucoleus crassa, Filaroides nigricans, Pearsonema gracilis, Strongyloides leonina and U. stenocephala; cestodes such as Mesocestoides tetrathyridial infection and other Taenia spp; and trematodes including Heterobilharzia americana and Nanophyetus salmincola. It is also an integral part of quarantine protocols in many research facilities for the control of Aspiculuris tetraptera and Syphacia spp infestation.fenben lab fenbendazol

Leave a Reply

Your email address will not be published. Required fields are marked *