Fenbendazole is an inexpensive, broad-spectrum anthelmintic that acts by inhibiting the polymerization of tubulin, a component of microtubules. It has been shown to have antitumor effects similar to those of cytotoxic anticancer agents.
The patient and her family began taking oral fenbendazole, which was marketed as an antiparasitic for dogs, after obtaining information from social media sites that it was effective against cancer.
- Fenbendazole is a fat soluble drug
Fenbendazole is a fat-soluble drug that can be administered orally. It is an effective treatment for a wide variety of parasites. It works by inhibiting microtubule formation in the parasites. It is also known to have anticancer activity. It is important to follow your veterinarian’s instructions carefully when administering this medication.
The anthelmintic fenbendazole (FEN) is a broad-spectrum benzimidazole that is used in veterinary medicine to treat intestinal parasites, including Giardia lamblia, roundworms, hookworms, whipworms, lungworms and the tapeworm genus Taenia (but not Dipylidium caninum). It has also been shown to have microtubule depolymerizing activity and may act as an antitumor agent.
Cell culture experiments using a variety of cell types have revealed that fenbendazole is able to induce microtubule depolymerization in human cancer cells and other cell types. This activity appears to be mediated by interactions with tubulin. Currently, fenbendazole is being investigated for its potential as an anticancer agent. Its mechanism of action is similar to that of hypoxia-selective nitroheterocyclic cytotoxins and radiosensitizers, taxanes and vinca alkaloids.
- Fenbendazole is a water soluble drug
Fenbendazole is a broad-spectrum benzimidazole anthelmintic that has been used to treat gastrointestinal parasites in various animal species. It is effective in destroying most helminths, including ascarids (Acaris spp.), whipworms (Trichuriasis) and tapeworms (Platynosomum fastosum). However, fenbendazole is insoluble in water, which limits its absorption and clinical efficacy.
This article describes the mechanochemical processing of fenbendazole to form a mesoscopic, amorphous drug with increased solubility. The drug was incorporated with cyclodextrins to improve its solubility. The resulting amorphous complex has been shown to be more bioavailable than the crystalline drug.
The amorphous complex has been shown to inhibit microtubule polymerization and prevent mitotic catastrophe in human cancer cells. It also shows significant anthelmintic activity in mice and sheep infected with H. nana and Trichuria spiralis at reduced doses. In addition, the amorphous drug is easy to handle and can be delivered by injection. Its high anthelmintic efficacy could lead to improved treatment of intestinal parasites in humans.
- Fenbendazole is an oral drug
Fenbendazole is a broad-spectrum, oral anthelmintic that is effective against the intestinal parasites giardia, roundworms, hookworms, whipworms, and the tapeworm genus Taenia. It also has activity against pulmonary paragonimiasis. It can be administered to dogs, cats, rabbits, guinea pigs, rodents, cattle, sheep, and horses. It is available as oral granules or as a liquid suspension. It should be given with food to reduce gastrointestinal side effects.
In addition to its antiparasitic action, fenbendazole has been shown to inhibit tumor growth in animal models. It acts by inhibiting the polymerization of tubulin, which makes up microtubules. This mechanism of action is similar to that of cytotoxic anticancer agents, such as vinca alkaloids and taxanes. In this way, fenbendazole may serve as a useful adjunct to other cancer therapies. In this study, fenbendazole was administered to a group of mice with tumors and found to significantly inhibit tumor growth. The results showed that fenbendazole was effective in suppressing the growth of both unirradiated and irradiated tumors.
- Fenbendazole is a topical drug
Fenbendazole is a broad spectrum benzimidazole anthelmintic that is effective against a number of intestinal parasites, including giardia, roundworms, hookworms, whipworms, and the tapeworm genus Taenia (but not Dipylidium caninum, a common dog tapeworm). It also has been used to treat lungworms in cats. It is given by mouth as oral granules or liquid suspension. It is sometimes prescribed for ‘off label’ use in other animals, such as rabbits, sheep, and horses.
It exerts its antiparasitic effects by binding to b-tubulin microtubule subunits and disrupting tubulin polymerization. It has also been shown to exhibit cytotoxic activity in cells. It is a potent inhibitor of cell division and has been shown to inhibit tumor growth in vivo.
The present invention provides a method for producing an aqueous suspension of fenbendazole. This aqueous formulation does not agglomerate or change in particle size after standing for twenty-four hours. It comprises a therapeutically effective amount of fenbendazole, a preservative and a surfactant.fenben lab fenbendazol